Prevalence of Various Forms of Active Tuberculosis in Patients with Diabetes
Active Tuberculosis in Patients with Diabetes
DOI:
https://doi.org/10.54393/tt.v4i03.170Keywords:
Tuberculosis, Prevalence, Diabetes, Multidrug-Resistant TBAbstract
A diabetic foot ulcer (DFU) is a persistent complication of diabetes mellitus. Diabetes is linked to a two to four-fold higher likelihood of developing peripheral arterial disease (PAD) when compared to individuals without diabetes. Objective: To determine the incidence of various forms of active tuberculosis in patients with diabetes. Methods: It was a cross-sectional study conducted at the Department of General Medicine from August 2022 to February 2023. 175 patients, including both males and females, participated in this study. Comprehensive demographic information was meticulously documented for each patient following the appropriate consent procedures. These patients had symptoms such as cough with or without phlegm, hemoptysis, persistent fever, and unexplained weight loss, and their ages ranged from 10 to 85 years. Comprehensive medical history, clinical examination, and TB screening tests were conducted and data analysis were done by SPSS version-24 for further analysis. Results: The mean age was 51.34 years with a standard deviation of 3.61. Among the patients, 107 (61.14%) were male, and 68 (38.85%) were female. The overall prevalence of active TB was 38 cases, accounting for 21.71% of the total. Among these cases, 18 were pulmonary TB, making up 47.36% of the active TB cases, while 13 were extra-pulmonary TB, constituting 34.21% of the total. Additionally, 5 cases were identified as multidrug-resistant TB, representing 13.15% of the active TB cases. Conclusions: In conclusion, our study reveals a higher prevalence of various forms of active tuberculosis in patients with diabetes with pulmonary tuberculosis accounting for 47.35% and extra pulmonary tuberculosis for 34.21% of cases.
References
Houben RMGJ and Dodd PJ. The global burden of latent tuberculosis infection: a re-estimation using mathematical modelling. PLoS Med. 2016 Oct; 13(10): e1002152. doi: 10.1371/journal.pmed.1002152.
Hayashi S and Chandramohan D. Risk of active tuberculosis among people with diabetes mellitus: systematic review and meta-analysis. Tropical Medicine and International Health. 2018 Oct; 23(10): 1058–70. doi: 10.1111/tmi.13133.
Huber FG, Kristensen KL, Holden IK, Andersen PH, Bakir B, Jørgensen A et al. The prevalence of diabetes among tuberculosis patients in Denmark. BMC Infectious Diseases. 2022 Dec; 22(1): 1-9. doi: 10.1186/s12879-022-07048-4.
Cadena J, Rathinavelu S, Lopez-Alvarenga JC, Restrepo BI. The re-emerging association between tuberculosis and diabetes: lessons from past centuries. Tuberculosis. 2019 May; 116: S89-97. doi: 10.1016/j.tube.2019.04.015.
Al-Rifai RH, Pearson F, Critchley JA, Abu-Raddad LJ. Association between diabetes mellitus and active tuberculosis: A systematic review and meta-analysis. PloS One. 2017 Nov; 12(11): e0187967. doi: 10.1371/journal.pone.0187967.
Kuruva P, Kandi SR, Kandi S. Clinico-radiological profile and treatment outcome of pulmonary tuberculosis with and without type 2 diabetes mellitus. Indian Journal of Tuberculosis. 2021 Apr; 68(2): 249-54. doi: 10.1016/j.ijtb.2020.09.020.
Dabhi PA, Thangakunam B, Gupta R, James P, Thomas N, Naik D, et al. Screening for prevalence of current TB disease and latent TB infection in type 2 diabetes mellitus patients attending a diabetic clinic in an Indian tertiary care hospital. PLoS One. 2020 Jun; 15(6): e0233385. doi: 10.1371/journal.pone.0233385.
Li Y, Guo J, Xia T, Wu F, Tian J, Cheng M, et al. Incidence of pulmonary tuberculosis in Chinese adults with type 2 diabetes: a retrospective cohort study in Shanghai. Scientific Reports. 2020 May; 10(1): 8578. doi: 10.1038/s41598-020-65603-y.
Park J, Yoon JH, Ki HK, Han K, Kim H. Lifestyle changes and risk of tuberculosis in patients with type 2 diabetes mellitus: A nationwide cohort study. Frontiers in Endocrinology. 2022 Oct; 13: 1009493. doi: 10.3389/fendo.2022.1009493.
Ko TH, Chang YC, Chang CH, Liao KC, Magee MJ, Lin HH. Prediabetes and risk of active tuberculosis: a cohort study from Northern Taiwan. International Journal of Epidemiology. 2023 Jun; 52(3): 932-41. doi: 10.1093/ije/dyac214.
Calculator.net. Sample size calculator. [Last Cited: 9th Dec 2023]. Available at: https://www.calculator.net/sample-size-calculator.html.
Araia ZZ, Kibreab F, Kibrom AA, Mebrahtu AH, Girmatsion MG, Teklehiwet YW et al. Determinants of unsuccessful tuberculosis treatment outcome in Northern Red Sea region, Eritrea. Plos One. 2022 Aug; 17(8): e0273069. doi: 10.1371/journal.pone.0273069.
Solanki HM, Ranpariya PN, Chudasama RK. Health Status and Treatment Outcome of Tuberculosis with Diabetes Mellitus Cases, Rajkot City, Gujarat–A Longitudinal Study. Indian Journal of Community Medicine. 2022; 35(3): 667-71.
Basit A, Zeb S, Umar M, Khan MU, Ullah I, Mehmood Z. The Frequency of Various Forms of Active Tuberculosis in Patients with Diabetes. MedForum. 2023; 34(8): 233-236.
Lee PH, Fu H, Lee MR, Magee M, Lin HH. Tuberculosis and diabetes in low and moderate tuberculosis incidence countries. The International Journal of Tuberculosis and Lung Disease. 2018 Jan; 22(1): 7-16. doi: 10.5588/ijtld.17.0329.
Tahir NB, Uddin QT, Munir SS, Waheed AB, Waheed SA, Daud HM. Prevalence of diabetes mellitus in tuberculosis patients at DOTS regional centre KMU-IMS teaching Hospital Kohat. Eureopean Academic Research. 2014 Oct; 2(7): 9948-59.
Khalid N, Ahmad F, Qureshi FM. Association amid the comorbidity of Diabetes Mellitus in patients of Active Tuberculosis in Pakistan: A matched case control study. Pakistan Journal of Medical Sciences. 2021 May; 37(3): 816. doi: 10.12669/pjms.37.3.3274.
Kermansaravi F, Metanat M, Sharifi-Mood B. Evaluation of active pulmonary tuberculosis among patients with diabetes. International Journal of Infection. 2014 May; 1(1): 1-. doi: 10.17795/iji-19632.
Masood T, Khan AM, Khan SA. Prevalence of Tuberculosis Among Patients having Diabetes Mellitis-A Cross-Sectional Study. Journal of Medical Health Sciences. 2016 Oct; 10(4): 1222-5.
Ali S, Aslam MI, Elahi NM, Khan WA, Musharaf MS, Javed Y. Prevalence of tuberculosis in diabetic patients. Pakistan Journal of Medical and Health Sciences. 2021 Apr; 15(5): 1058-60. doi: 10.53350/pjmhs211551058.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 THE THERAPIST (Journal of Therapies & Rehabilitation Sciences)
This work is licensed under a Creative Commons Attribution 4.0 International License.
This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For comments editor@thetherapist.com.pk